Word editions · 12 October 2026

Research review downloads

23 Word editions from 12 October 2026, with links to the research reviews.

The 12 October edition record describes the Word files and web text at that date. On 7 November the nuclear speckles web review was revised and the two chromatin web reviews were merged. Their October Word editions remain available below. Citations use primary studies and selected seminal reviews.

Read the edition and evidence record. Source access ranges from primary abstracts to inspected Results, Methods and figure captions and is documented in each webpage bibliography. Searches are topic specific; these editions do not claim exhaustive literature coverage.

Chromatin and gene regulation

Mitotic chromosome condensation: assembly, topology and dynamic architecture

How condensin motors, nucleosomes and DNA topology produce individualized chromosomes, and what each experiment actually measures.

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Chromatin biophysics: nucleosome interactions, genome folding and mechanical response

A multiscale account connecting molecular accessibility to heterogeneous structure, chromosome dynamics and force transmission.

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Chromatin condensates: mechanisms, evidence and cellular context

What purified arrays and chromatin-binding proteins demonstrate, and how to distinguish phase separation from other forms of organization.

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Euchromatin: accessibility, regulatory competence and dynamic genome organization

A current synthesis of how nucleosomes, remodeling, regulatory elements and chromosome folding support an accessible genome.

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Heterochromatin: establishment, inheritance and heterogeneous physical organization

Repressive chromatin as a regulated domain system, with current evidence for molecular recognition, maintenance dynamics and local architecture.

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Histone post-translational modifications: chemistry, recognition and chromatin memory

From defined molecular effects to replication-coupled restoration, damage signaling and metabolic regulation.

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Histone modifications in neurodegeneration: disease associations, mechanisms and current evidence

Alzheimer-related acetylation, polyglutamine models and mitochondrial Parkinson mechanisms, with cell-type and causal interpretation.

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Transcriptional condensates and hubs: recruitment, reaction environments and alternative mechanisms

Current primary evidence for coactivator assemblies, RNA and phosphorylation regulation, elongation-linked condensates and gene-associated polymerase clusters.

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Nuclear bodies and RNA biology

The Orchestration of Eukaryotic Gene Expression

Molecular coupling, nuclear organization and the measured flow of RNA from synthesis to export

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Nuclear Bodies: Molecular Assembly and Compartment-Specific Function

A comparative synthesis of nucleoli, speckles, paraspeckles, Cajal bodies and PML bodies

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Cajal Bodies: RNP Assembly, Dynamic Organization and Physiological Context

Coilin, guide RNAs, spliceosomal particle maturation and the conditional relationship to telomerase

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Paraspeckles: RNA Architecture, Assembly and Conditional Function

NEAT1 isoforms, ordered ribonucleoprotein organization and stress-dependent regulation

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PML Nuclear Bodies: Assembly, SUMO Networks and Conditional Biological Functions

Structural organization, dynamic recruitment, chromatin control and protein quality regulation

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The Nucleolus: Ribosome Biogenesis, RNA Flux and Multiphase Organization

RNA processing links molecular assembly, layered architecture, material properties and stress signaling

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Nuclear biophysics and the nuclear boundary

Nuclear Microrheology: Measuring Local Response in a Living Composite

From fluorescent tracers to calibrated forces and frequency-dependent mechanics

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Nuclear Viscosity: Fluid Resistance, Structural Relaxation and Biological State

A current account of what mobility and mechanical experiments measure

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Nuclear Macromolecular Crowding: Accessibility, Association and Spatial Organization

How chromatin, volume and molecular interactions shape the nuclear reaction environment

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Nuclear Biophysics: A Decade of Composite Mechanics and Molecular Organization

Integrated structural, transport and force-based evidence through 2026

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The Nuclear Envelope: Membranes, Genome Coupling and Regulated Remodeling

A complete current synthesis of boundary structure and function

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The Nuclear Lamina: Filament Architecture, Genome Attachment and Cell Function

A current synthesis of structural, mechanical and genetic evidence

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Nuclear Pore Complexes: Architecture, Selective Transport and Plasticity

Integrated primary evidence from structural scaffolds to current barrier dynamics

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Nuclear Transport and Compartment Dynamics: Gates, Search and Processing

A unified review that preserves the distinction between boundary exchange and internal movement

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Original Word draft archive — 20 files

The original files are retained unchanged for historical comparison. They are earlier drafts with incomplete scientific validation. The two Cajal-body drafts are represented by one current Cajal-body edition above.