Reverse-Engineering the Spliceosome
Biophysics of Cajal bodies and snRNP assembly pathways.
RNA Splicing
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FIB-SEM Studies
High-resolution focused ion beam scanning electron microscopy revealing nuclear ultrastructure and chromatin organization in unprecedented detail.
Data courtesy of Janelia Farms Research Campus
Macrophage Nucleus - PcG Subregions
Technique: FIB-SEM multiview reconstruction
Sample: Macrophage nucleus showing Polycomb group (PcG) protein subregions
Resolution: Nanometer-scale 3D visualization
File Size: 381 MB
Featured Video
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PcG Subregion Analysis - View 3
Technique: FIB-SEM serial sectioning
Focus: Alternative view of PcG subregion organization
Application: Chromatin territory mapping
File Size: 76.8 MB
High Resolution
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Shadow Volume Reconstruction
Technique: Shadow volume visualization
Enhancement: 3D depth perception through shadow mapping
Purpose: Structural context and spatial relationships
File Size: 148.6 MB
3D Visualization
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HeLa Cell Analysis - Figure 1
Cell Type: HeLa cervical cancer cell line
Application: Publication-quality figure generation
Features: Complete nuclear architecture visualization
File Size: 300.7 MB
Publication Quality
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Live-Cell Imaging
Dynamic visualization of nuclear processes in living cells, capturing real-time molecular movements and structural changes within the nuclear environment.
Nuclear Speckles Dynamics
Technical Details
Technique: Live-cell fluorescence microscopy
Marker: GFP-labeled nuclear speckle proteins
Cell Line: HeLa cervical cancer cells
Duration: Time-lapse sequence
File Size: 15.6 MB
Biological Significance
Nuclear speckles are dynamic subnuclear compartments enriched in pre-mRNA splicing factors.
This visualization captures their mobility and structural reorganization during cellular processes.
Critical for understanding RNA processing and gene expression regulation.
Live Imaging
GFP Fluorescence
View Nuclear Speckles Reviews
Data Attribution
All FIB-SEM datasets presented in this gallery were generously provided by Janelia Farms Research Campus, a world-leading institution in biological imaging and neuroscience research.
Advanced Imaging Facility
Open Science Initiative
Research Collaboration
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